The Claim
Triiodothyronine administration upregulates 381 genes in human skeletal muscle, including key components of the ubiquitin-proteasome pathway and mitochondrial respiratory chain, indicating coordinated transcriptional activation of protein degradation and energy production systems.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Administration of triiodothyronine increases the activity of 381 genes in human skeletal muscle, specifically enhancing genes involved in breaking down proteins and producing cellular energy.
See the scientific wording
Triiodothyronine administration upregulates 381 genes in human skeletal muscle, including key components of the ubiquitin-proteasome pathway and mitochondrial respiratory chain, suggesting coordinated transcriptional activation of protein degradation and energy production systems.
Thyroid hormone enters muscle cells and binds to receptors in the nucleus, which turn on hundreds of genes that build the machinery to break down proteins and produce energy. This includes making more components of the protein-shredding system and more parts of the cellular power plants, while also strengthening the muscle's internal structure and improving its ability to respond to other hormones.
What the research says
1 studyStudy: In vivo regulation of human skeletal muscle gene expression by thyroid hormone.
When healthy men took a synthetic thyroid hormone, their muscles turned on hundreds of genes that help break down proteins and make energy — exactly what the claim says happened.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.