The Claim

Human colon organoids co-cultured with colibactin-producing Escherichia coli for three months exhibit the SBS-pks DNA mutation signature, which is identical to the mutational pattern observed in human colorectal tumors.

Source: Abstract 2796: Colibactin mutation signatures are associated with younger age of onset in colorectal cancer

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
44score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

When human colon tissue grown in the lab is exposed to a specific type of E. coli that produces colibactin for three months, it develops a unique pattern of DNA damage that matches the pattern seen in human colorectal cancers.

See the scientific wording

Human colon organoids co-cultured with colibactin-producing E. coli for three months develop the same DNA mutation signature (SBS-pks) observed in human colorectal tumors, providing experimental evidence that colibactin can induce this mutational pattern in human tissue.

What the research says

1 study

  1. Study: Abstract 2796: Colibactin mutation signatures are associated with younger age of onset in colorectal cancer

    Scientists grew human colon cells with a specific type of bacteria that makes a DNA-damaging toxin. After three months, the cells developed the exact same DNA damage pattern seen in colon cancer patients, proving the bacteria can cause this kind of damage.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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