A form of vitamin D can calm down overactive immune cells in the body by turning down a specific molecule that causes inflammation, which helps the body produce a protein that reduces swelling and irritation.

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Pro

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Against

Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155–SOCS1 in Macrophages

Case-Control Study

Animal

2013 Apr 1

Vitamin D helps calm down overactive immune cells by turning down a molecule called miR-155, which normally blocks a natural brake on inflammation called SOCS1. When vitamin D reduces miR-155, SOCS1 can work better to stop excessive inflammation.

Contradicting (0)

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No contradicting evidence found

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Source Study

1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155–SOCS1 in Macrophages

Score: 12

DOI: 10.4049/jimmunol.1203273

Similar Assertions

A form of vitamin D can calm down immune cells when they overreact to bacteria by turning off a key inflammation signal, which helps produce a protein that puts the brakes on the immune response.

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When scientists removed a tiny gene regulator called miR-155 from mice that lacked vitamin D receptors, the mice’s immune systems didn’t go into overdrive anymore. This suggests that too much of this gene regulator is what makes the inflammation worse when vitamin D is low.

12

0

81%

Vitamin D helps calm inflammation in certain immune cells by stopping a specific switch in the cell’s DNA from turning on a molecule that causes inflammation.

12

0

75%