The Claim

In healthy adult humans, euglycemic hyperinsulinemic clamp conditions increase leg blood flow from approximately 0.30 to 0.48 liters per minute, resulting in a near doubling of skeletal muscle perfusion independent of changes in blood glucose levels, demonstrating that insulin exerts direct vascular effects.

Source: Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
38score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

When insulin goes up in healthy people — without changing blood sugar — blood flow to the legs nearly doubles, showing insulin itself can widen blood vessels.

See the scientific wording

In healthy adult humans, euglycemic hyperinsulinemic clamp conditions increase leg blood flow from approximately 0.30 to 0.48 liters/min, representing a near doubling of skeletal muscle perfusion independent of glucose changes, indicating insulin has direct vascular effects.

What the research says

1 study
  1. Study: Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

    The study shows that insulin increases blood flow to the legs in healthy people without changing blood sugar, just like the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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