When insulin goes up in healthy people — without changing blood sugar — blood flow to the legs nearly doubles, showing insulin itself can widen blood vessels.

38

Pro

0

Against

Evidence from Studies

Supporting (1)

38

Community contributions welcome

38

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

Cross-Sectional Study

Human

1994 Sep

The study shows that insulin increases blood flow to the legs in healthy people without changing blood sugar, just like the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

Score: 38

DOI: 10.1172/JCI117433

Similar Assertions

When insulin levels go up in healthy adults, it helps blood flow better in the legs by turning on a molecule called nitric oxide — and it works about twice as well as when insulin isn’t active.

38

0

83%

When healthy adults get a controlled dose of insulin for two hours, it boosts blood flow and blood volume in their heart and muscle tissues, helping more nutrients move between blood and muscles.

54

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71%