When insulin levels get really high in the blood (around 110 units), it strongly stops the liver from making ketone bodies (which the body makes when breaking down fats), cutting the production rate by more than half in healthy people.

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Against

Evidence from Studies

Supporting (1)

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Community contributions welcome

33

Fatty acid-independent inhibition of hepatic ketone body production by insulin in humans.

Cross-Sectional Study

Human

1988 Jun

The study gave people extra fat (Intralipid) to raise their fatty acid levels, then measured how much ketone bodies their livers produced. When insulin was kept low, ketone production went up to 8.2. When insulin was raised to about 110 microU/ml, ketone production dropped to only 3.8 - exactly matching what the claim says.

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No contradicting evidence found

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Source Study

Fatty acid-independent inhibition of hepatic ketone body production by insulin in humans.

Score: 33

DOI: 10.1152/AJPENDO.1988.254.6.E694

Similar Assertions

When healthy adults haven't eaten overnight and have low insulin levels, having higher levels of fatty acids in their blood (about double the normal amount) makes their liver produce more than twice as many ketone bodies - the molecules your body makes when breaking down fat for energy.

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89%

When doctors raise a hormone called glucagon in healthy people's blood by giving them fatty acids, it doesn't change how much ketone (a chemical the liver makes) their bodies produce.

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76%

When your body makes less insulin (like during fasting or on a low-carb diet), it starts producing more ketones - these are alternative fuel molecules your body can use instead of sugar.

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75%