The Claim
The addition of 48–54 mg/day of kahweol to 60 mg/day of cafestol increases alanine aminotransferase by 35 U/L (P=0.004) and does not significantly alter serum lipid levels, indicating that kahweol enhances cafestol’s effect on liver enzymes without increasing its effect on serum lipids.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Adding kahweol to cafestol raises a liver enzyme called alanine aminotransferase by 35 U/L without changing serum lipid levels.
See the scientific wording
The addition of 48–54 mg/day of kahweol to 60 mg/day of cafestol further increases alanine aminotransferase by 35 U/L (P=0.004) but has no statistically significant additional effect on serum lipids, indicating that kahweol potentiates cafestol’s effect on liver enzymes without amplifying its hyperlipidemic activity.
Cafestol triggers liver cells to activate stress pathways that increase enzyme release into the blood. Kahweol strengthens this same stress response in liver cells, causing more enzyme to leak out, but does not change how the liver handles fats.
What the research says
1 studyWhen kahweol is added to cafestol, it makes a liver enzyme go up a lot, but doesn’t make cholesterol or triglycerides go up any more than cafestol alone. So kahweol affects the liver differently than it affects fats in the blood.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.