mechanistic
Analysis v1
Strong Support
When scientists removed a tiny gene regulator called miR-155 from mice that lacked vitamin D receptors, the mice’s immune systems didn’t go into overdrive anymore. This suggests that too much of this gene regulator is what makes the inflammation worse when vitamin D is low.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155–SOCS1 in Macrophages
Case-Control Study
Animal
2013 Apr 1When mice don’t have enough vitamin D signaling, their immune cells go into overdrive because a tiny molecule called miR-155 gets too active. When scientists removed miR-155, the overactive inflammation stopped — proving miR-155 is the culprit.
Contradicting (0)
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No contradicting evidence found
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