In mice eating a bad diet, a drug called GW501516 might help keep a key energy-sensing switch in the liver working properly, which could help their bodies handle the stress of unhealthy eating.

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The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

Cross-Sectional Study

Animal

2011 May

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Source Study

The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

Score: 12

DOI: 10.1210/en.2010-1468

Similar Assertions

In mice on a high-fat diet, a drug called GW501516 might boost a specific fat in the liver that could help turn on a fat-burning switch, making the body burn fat more efficiently.

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In mice on a high-fat diet, a drug called GW501516 might help liver cells better manage fat by turning up a key protein and activating a fat-burning switch.

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In mice eating a fatty diet, a drug called GW501516 seems to turn on a chain reaction in the liver that helps burn fat more efficiently.

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In mice eating a high-fat diet, taking a drug called GW501516 seems to boost a substance in their blood that shows their liver is burning more fat for energy.

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Turning on a protein called AMPK tells another protein, PPARα, to switch on genes that help the body burn fat for energy.

70%