When mice eat a very low-carb diet, their fat tissue mitochondria use more of a specific healthy fat (C18:2) and less of another (C22:6)
Scientific Claim
Ketogenic diet increases C18:2 and C20:4 content in brown adipose tissue phosphatidylethanolamine while decreasing C22:6 content
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study demonstrates an association between ketogenic diet and specific changes in phospholipid composition in mice. The language 'increases' and 'decreases' is appropriate for this mouse model study.
More Accurate Statement
“Ketogenic diet is associated with increased C18:2 and C20:4 content in brown adipose tissue phosphatidylethanolamine while decreasing C22:6 content”
Source Excerpt
“Even though there was still a higher C22:6 amount in the WT in PE, the overall C22:6 dropped significantly in PE from >20% to ~10%, offset by increases in C18:2 and C20:4”
Evidence from Studies
Supporting Evidence (1)
Lipidomics analysis of BAT on ketogenic diet showed decreased C22:6 in PE (from >20% to ~10%) with compensatory increases in C18:2 and C20:4, indicating diet-induced adaptation in membrane lipid composition.
Excess dietary carbohydrate affects mitochondrial integrity as observed in brown adipose tissue