When mice fasted, MOTS-c levels dropped in muscles and blood but stayed the same in brain and heart.

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Evidence from Studies

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Contradicting (1)

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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Randomized Controlled Trial

Animal

2015 Mar 3

This study didn't test what happens to MOTS-c when mice fast—it only tested what happens when scientists give mice extra MOTS-c, which helped them stay healthy. So we can't say if fasting changes MOTS-c levels.

Source Study

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Score: 13

DOI: 10.1016/j.cmet.2015.02.009

Similar Assertions

As mice get older, their bodies make less of a peptide called MOTS-c, especially in muscles and blood—and when they fast, levels drop too, hinting that this peptide responds to energy needs.

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MOTS-c didn’t make mice move more, so its effects on weight and metabolism aren’t just because they were exercising more.

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13

71%