MOTS-c didn’t make mice move more, so its effects on weight and metabolism aren’t just because they were exercising more.
Scientific Claim
In mice, MOTS-c treatment did not alter total physical activity levels, indicating that its metabolic effects are not secondary to increased movement.
Original Statement
“Total activity was comparable between the 2 groups.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim is a simple descriptive observation with no causal implication. The language is appropriate for the evidence.
More Accurate Statement
“In mice, MOTS-c treatment was associated with no change in total physical activity levels, indicating that its metabolic effects are not secondary to increased movement.”
Evidence from Studies
Supporting (0)
Contradicting (1)
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
The study shows MOTS-c helps mice stay healthy and not get fat, but it never checked if the mice moved more or less, so we can't say if the health benefits are because they moved more or not.