MOTS-c didn’t make mice move more, so its effects on weight and metabolism aren’t just because they were exercising more.

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No supporting evidence found

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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Randomized Controlled Trial

Animal & In Vitro

2015 Mar 3

Mice given MOTS-c burned more sugar for energy and produced more body heat—even though they didn’t move around more than the control mice.

77%

When mice fasted, MOTS-c levels dropped in muscles and blood but stayed the same in brain and heart.

71%

Obese mice given MOTS-c had lower levels of suberate, a dicarboxylic acid, by 40% compared to untreated mice.

70%