Mice given MOTS-c burned more sugar for energy and produced more body heat—even though they didn’t move around more than the control mice.

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Pro

13

Against

Evidence from Studies

Supporting (0)

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No supporting evidence found

Contradicting (1)

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Community contributions welcome

13

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Randomized Controlled Trial

Animal

2015 Mar 3

The study says MOTS-c helps mice stay healthy and not get fat, but it never measured if they burned more energy or used more sugar like the claim says.

Source Study

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Score: 13

DOI: 10.1016/j.cmet.2015.02.009

Similar Assertions

MOTS-c injections made mice burn more glucose instead of fat, as shown by higher CO2 output relative to oxygen use.

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13

83%

MOTS-c didn’t make mice move more, so its effects on weight and metabolism aren’t just because they were exercising more.

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13

77%

MOTS-c made muscle cells produce more GLUT4 (a sugar transporter) and turned on AMPK (an energy sensor), two key players in how muscles use sugar.

13

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71%