MOTS-c injections made mice burn more glucose instead of fat, as shown by higher CO2 output relative to oxygen use.

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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Randomized Controlled Trial

Animal

2015 Mar 3

The study says MOTS-c helps mice stay healthy on a high-fat diet, but it never measured whether they burned more sugar instead of fat, which is what the claim is about.

Source Study

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Score: 13

DOI: 10.1016/j.cmet.2015.02.009

Similar Assertions

Mice given MOTS-c burned more sugar for energy and produced more body heat—even though they didn’t move around more than the control mice.

83%

Obese mice given MOTS-c injections for three days had lower blood sugar levels than mice that didn't receive the treatment.

77%

Obese mice given MOTS-c had lower levels of suberate, a dicarboxylic acid, by 40% compared to untreated mice.

74%

Mice that ate a fatty diet and got daily MOTS-c shots didn’t get as fat as mice that didn’t get the shots—even though they ate the same amount of food.

71%

When mice ate a high-fat diet, daily MOTS-c injections helped them stay lighter than untreated mice, even though they ate the same amount of food.

70%