Mice that ate a fatty diet and got daily MOTS-c shots didn’t get as fat as mice that didn’t get the shots—even though they ate the same amount of food.

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Evidence from Studies

Supporting (1)

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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Randomized Controlled Trial

Animal

2015 Mar 3

The study found that giving mice a tiny protein from their mitochondria stopped them from getting fat on a junk food diet—even though they ate the same amount—so it might help fight obesity without needing to eat less.

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Source Study

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Score: 13

DOI: 10.1016/j.cmet.2015.02.009

Similar Assertions

MOTS-c injections reduced fat buildup in the livers of mice eating a high-fat diet, as seen in tissue samples.

86%

When mice ate a high-fat diet, daily MOTS-c injections helped them stay lighter than untreated mice, even though they ate the same amount of food.

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Obese mice given MOTS-c injections for three days had lower blood sugar levels than mice that didn't receive the treatment.

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MOTS-c treatment in obese mice reduced the activity of a liver enzyme called Por by half, which may affect fat metabolism.

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Obese mice given MOTS-c had lower levels of suberate, a dicarboxylic acid, by 40% compared to untreated mice.

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