MOTS-c injections reduced fat buildup in the livers of mice eating a high-fat diet, as seen in tissue samples.

Mice that ate a fatty diet and got daily MOTS-c shots didn’t get as fat as mice that didn’t get the shots—even though they ate the same amount of food.

MOTS-c treatment in obese mice reduced the activity of a liver enzyme called Por by half, which may affect fat metabolism.

MOTS-c injections in obese mice reduced a type of fat molecule called 2-oleoylglycerol by about 32% compared to untreated mice.

Obese mice given MOTS-c had lower levels of suberate, a dicarboxylic acid, by 40% compared to untreated mice.

When mice ate a high-fat diet, daily MOTS-c injections helped them stay lighter than untreated mice, even though they ate the same amount of food.