mechanistic
Analysis v1
Strong Support
When a specific protein called ATM doesn't work properly, skin stem cells that should stay as stem cells start turning into the wrong kind of cells. This protein acts like a guard that keeps stem cells healthy and in the right state.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
Cohort Study
Animal
2009 Jun 12When a key protein called ATM is missing, hair stem cells turn into pigment cells too early instead of staying as stem cells, which causes hair to turn gray. This shows ATM acts like a guard that keeps stem cells healthy and in place.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.