The Claim

In mice treated with the myostatin inhibitor sActRIIB-Fc, resistance exercise training increases hindlimb muscle mass by approximately 14% compared to myostatin inhibition alone.

Source: Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
14score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

In mice given a myostatin inhibitor, adding resistance exercise increases hindlimb muscle mass by about 14% more than the inhibitor alone.

See the scientific wording

In mice treated with a myostatin inhibitor (sActRIIB-Fc), resistance exercise training increased hindlimb muscle mass by approximately 14% beyond the gain from myostatin inhibition alone, suggesting that mechanical loading enhances muscle accretion when myostatin signaling is suppressed.

Why this might work

When a muscle growth blocker is turned off, muscles start to grow. Adding resistance exercise makes them grow even more by reducing the rate at which muscle proteins are broken down and increasing signals that build new muscle fibers.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice

    When mice were given a drug that blocks a muscle-growth limiter and also made to do strength exercises, their muscles grew bigger than mice that only got the drug. This shows that exercise can make muscles grow even more, even when the body’s natural brake on muscle size is turned off.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.