The Claim

In murine C2C12 skeletal myotubes, treatment with 1,25(OH)2-vitamin D3 increases mRNA expression of both the insulin receptor and the vitamin D receptor.

Source: 1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
9score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

When scientists add a form of vitamin D to mouse muscle cells in a dish, the cells start making more of two important proteins: one that helps them respond to insulin, and one that helps them respond to vitamin D itself.

See the scientific wording

In murine C2C12 skeletal myotubes, treatment with 1,25(OH)2-vitamin D3 increases mRNA expression of both the insulin receptor and the vitamin D receptor.

What the research says

1 study

  1. Study: 1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes.

    The study gave mouse muscle cells a form of vitamin D and found that the cells made more of the messages (mRNA) for both the insulin receptor and the vitamin D receptor — exactly what the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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