mechanistic
Analysis v1
16
0
When mouse skin is exposed to UV light, pigment cells temporarily turn dark but later revert back to stem cells.
Scientific Claim
UVB irradiation in mice is associated with temporary differentiation of melanocyte stem cells followed by dedifferentiation.
Original Statement
“McSCs that are driven to fulfill their ultimate differentiated function of producing visible pigment following UVB irradiation can still revert to an undifferentiated state.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
Uses 'associated with' and describes the sequence of events without implying causation, consistent with study design limitations.
Evidence from Studies
Supporting (1)
16
16
Dedifferentiation maintains melanocyte stem cells in a dynamic niche
Cohort Study
Animal
2023 AprContradicting (0)
0
No contradicting evidence found