The Claim

In human primary myoblasts, 1,25-dihydroxyvitamin D3 induces a dose-dependent increase in CYP24A1 mRNA expression, with 1 nmol/L causing an 8,634-fold increase compared to baseline, confirming functional vitamin D signaling in human muscle cells.

Source: Effects of 1,25-Dihydroxyvitamin D3 and Vitamin D3 on the Expression of the Vitamin D Receptor in Human Skeletal Muscle Cells

What the research says

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Supports
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Challenges
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These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
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In plain English

When scientists add a form of vitamin D to human muscle cells in a lab, the cells start making a lot more of a specific molecule—like turning up a volume knob—showing that these muscle cells can respond to vitamin D.

See the scientific wording

In human primary myoblasts, 1,25-dihydroxyvitamin D3 induces a dose-dependent increase in CYP24A1 mRNA expression, with 1 nmol/L causing an 8,634-fold increase compared to baseline, confirming functional vitamin D signaling in human muscle cells.

Score breakdown, mechanism chain, raw evidence, ideal studies needed

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