The Claim
In obese adults undergoing yellow fever immunization, serum glucagon levels increase on day 1 when consuming a protein-sparing modified fast containing 100 grams of glucose, but do not increase when consuming the same protein-sparing modified fast without glucose.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In obese adults receiving a yellow fever vaccine, blood glucagon levels rise on the first day if they consume a low-protein fast with 100 grams of glucose, but remain unchanged if they consume the same fast without glucose.
See the scientific wording
The metabolic response to yellow fever immunization in obese adults includes a rise in serum glucagon on day 1 when consuming a protein-sparing modified fast with 100 grams of glucose, but not when consuming the same fast without glucose.
When a person eats 100 grams of glucose while on a low-carb, high-protein diet, their pancreas releases a lot of insulin. This insulin stops the body from breaking down fat and making ketones. When the person gets a yellow fever vaccine, their body needs to keep blood sugar stable, but without ketones to use as fuel, the liver must make more glucose. To do this, the pancreas releases glucagon, which tells the liver to release stored sugar. Without glucose, ketones are available as fuel, so glucagon doesn't need to rise.
What the research says
1 studyWhen obese people on a low-carb, high-protein diet got a yellow fever shot, only those who ate 100g of sugar that day had a spike in glucagon — the others didn't. So sugar made the difference.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.