The Claim

The metabolite CDAA, derived from octocrylene, achieves significantly higher plasma concentrations (up to 1352 μg/L) and urinary excretion rates (up to 5207 μg/g creatinine) than octocrylene itself following sunscreen application, indicating extensive metabolic conversion and prolonged systemic exposure.

Source: Systemic availability of lipophilic organic UV filters through dermal sunscreen exposure.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
25score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

After using sunscreen containing octocrylene, the body converts it into a compound called CDAA, which builds up to much higher levels in the blood and urine than the original chemical.

See the scientific wording

The metabolite CDAA, derived from octocrylene, reaches significantly higher plasma concentrations (up to 1352 μg/L) and urinary excretion rates (up to 5207 μg/g creatinine) than its parent compound, indicating extensive metabolic conversion and prolonged systemic exposure following sunscreen use.

Why this might work

When sunscreen is applied to the skin, the oil-based ingredient octocrylene passes through the outer skin layer and enters the bloodstream. The body breaks down octocrylene into a different chemical called CDAA, which stays in the blood much longer and builds up to higher levels. CDAA is then filtered by the kidneys and removed in urine at much higher amounts than the original ingredient.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: Systemic availability of lipophilic organic UV filters through dermal sunscreen exposure.

    When people use sunscreen with octocrylene, their bodies turn much of it into a different chemical called CDAA, which builds up way more in the blood and pee than the original sunscreen ingredient. This study proved that happens in real people using sunscreen normally.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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