When people are obese, men’s fat tissue is less responsive to insulin than women’s, meaning their bodies have a harder time using insulin to manage fat storage — and this difference is very clear in studies.

49

Pro

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Against

Evidence from Studies

Supporting (1)

49

Community contributions welcome

49

Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1

Cross-Sectional Study

Human

2024 Jul

In obese people, men’s fat tissue is less responsive to insulin than women’s, making it harder for their bodies to stop fat breakdown — and this difference is big enough to be statistically proven in the study.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1

Score: 49

DOI: 10.1038/s41366-024-01501-x

Similar Assertions

When it comes to storing fat, insulin works the same way in obese men and women — but where they differ is in how well their bodies can break down fat, not how well they store it.

49

0

82%

In people with obesity, women’s fat tissue under the skin has about 60% more of a specific molecule (IRS1) that helps respond to insulin than men’s, and this difference is real—not just due to chance.

49

0

75%