In studies linking physical activity to colorectal cancer risk, the connection appears weaker when people diagnosed with cancer shortly after blood tests are removed, suggesting that early, undetected cancer may affect activity levels rather than activity causing cancer.

People who are more physically active tend to have a lower risk of developing colorectal cancer, while those who spend more time sitting have a higher risk.

Adults who sit for more than 8 hours a day but engage in at least 2000 MET-minutes of physical activity per week have a significantly lower risk of developing colorectal cancer compared to those who are less active.

People who engage in less than 600 MET-minutes of physical activity per week may not receive the protective benefit against colorectal cancer that higher activity levels provide, even if they reduce sedentary time.

People who are more physically active have a 10% lower risk of developing colorectal cancer compared to those who are less active, based on standardized activity measurements.

People who engage in more physical activity have a lower risk of developing cancer overall, with particularly lower risks for colorectal cancer and colonic adenomas, based on data from large long-term studies of over a million adults.