Low LDL cholesterol probably isn't causing illnesses like cancer or depression — it's more likely that these diseases are lowering cholesterol as a side effect.

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Evidence from Studies

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Can LDL cholesterol be too low? Possible risks of extremely low levels

Narrative Review

Human

2017 Jun

The study says that low cholesterol isn’t causing illnesses like cancer or depression—instead, those illnesses might be lowering cholesterol, which supports the claim.

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Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Can LDL cholesterol be too low? Possible risks of extremely low levels

Score: 1

DOI: 10.1111/joim.12614

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