The Claim

Supplementation with 10 grams of creatine monohydrate and 2 grams of guanidinoacetic acid for six weeks significantly improves correct incongruent reaction time by 38.8% in healthy adults during the Stroop test compared to supplementation with creatine monohydrate alone.

Source: Effects of 6 weeks of high-dose creatine monohydrate supplementation with or without guanidinoacetic acid on cognitive function

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
68score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

Taking 10 grams of creatine monohydrate and 2 grams of guanidinoacetic acid daily for six weeks improves reaction time accuracy by 38.8% during a cognitive test that measures executive control, compared to taking creatine monohydrate alone.

See the scientific wording

Supplementation with 10 grams of creatine monohydrate and 2 grams of guanidinoacetic acid for six weeks significantly improves correct incongruent reaction time by 38.8% in healthy adults during the Stroop test compared to creatine monohydrate alone, indicating enhanced executive control under cognitive conflict.

Why this might work

Taking creatine and its precursor together increases the brain's energy reserves, allowing nerve cells to recharge faster when they need to send signals quickly. This lets the brain make correct decisions faster when it's distracted by conflicting information.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Effects of 6 weeks of high-dose creatine monohydrate supplementation with or without guanidinoacetic acid on cognitive function

    People who took both creatine and guanidinoacetic acid together got much faster at making correct decisions when distracted, compared to those who only took creatine. The study proved this difference was real and not due to chance.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.