In adults with obesity, reducing social isolation is associated with a 36% decrease in the higher risk of death linked to obesity, making their mortality risk similar to that of people without...
Mechanism
Synthesis from 1 study
When people with obesity feel less alone, their bodies experience less stress, which helps their metabolism work better and reduces harmful swelling in tissues. This lowers their risk of heart problems and early death, bringing it closer to that of people without obesity.
Most probable mechanism
When people with obesity feel less alone and more connected, their bodies produce less of the stress hormone cortisol. This helps their metabolism work better and reduces harmful inflammation, which lowers the chance of early death.
Decreased perceived social isolation reduces activation of the hypothalamic-pituitary-adrenal (HPA) axis
Lower HPA axis activity leads to reduced circulating cortisol levels
Reduced cortisol improves insulin sensitivity and decreases visceral fat accumulation
Lower cortisol and improved metabolic function reduce systemic inflammation and endothelial dysfunction
Decreased inflammation and improved vascular function lower risk of cardiovascular events and all-cause mortality
Less supported by current evidence, but not ruled out
Feeling more connected may activate the body's calming nerve system, which slows heart rate and reduces inflammation, helping protect against early death.
Increased social connectedness enhances parasympathetic nervous system activity via the vagus nerve
Increased vagal tone suppresses pro-inflammatory cytokine production
Reduced inflammation improves metabolic and cardiovascular function
Evidence from Studies
Supporting (1)
Community contributions welcome
Improvement of Social Isolation and Loneliness and Excess Mortality Risk in People With Obesity
Contradicting (0)
Community contributions welcome
Gold Standard Evidence Needed
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