When PGC-1α is increased in muscle cells, they break down a specific type of fat (lignoceric acid) more efficiently using both peroxisomes and mitochondria. This finding is from the abstract summary - full study details were not available

Scientific Claim

PGC-1α overexpression is associated with increased oxidation of lignoceric acid by peroxisomal and mitochondrial activity in human primary myotubes.

Original Statement

“a concomitant increase in lignoceric acid oxidation by both peroxisomal and mitochondrial activity was observed (P < 0.05)”

From study:Overexpression of PGC-1α increases peroxisomal activity and mitochondrial fatty acid oxidation in human primary myotubes.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim uses 'associated with' which matches the recommended verb strength for this study design.

Evidence from Studies

Supporting (1)

Overexpression of PGC-1α increases peroxisomal activity and mitochondrial fatty acid oxidation in human primary myotubes.

Cross-Sectional Study

Human

2017 Apr 1

Contradicting (0)

No contradicting evidence found

Source Study

Overexpression of PGC-1α increases peroxisomal activity and mitochondrial fatty acid oxidation in human primary myotubes.

Score: 33

DOI: 10.1152/ajpendo.00331.2016

Similar Assertions

Increasing PGC-1α in muscle cells leads to higher levels of mRNA for breaking down fats in peroxisomes. This finding is from the abstract summary - full study details were not available

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When muscle cells in a lab have more PGC-1α protein, they show higher levels of PMP70, which is a protein involved in peroxisome function. This finding is from the abstract summary - full study details were not available

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