When healthy young men eat a lot of phosphate, their body makes more FGF23, which seems to lower the active form of vitamin D and raise a hormone called PTH — like the body is trying to balance things out.

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Pro

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Against

Evidence from Studies

Supporting (1)

54

Community contributions welcome

54

Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels

Randomized Controlled Trial

Human

2025 Mar

When these men ate more phosphate, their bodies made more FGF23, which lowered their active vitamin D and went hand-in-hand with higher PTH — just like the claim said.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Controlled dietary phosphate loading in healthy young men elevates plasma phosphate and FGF23 levels

Score: 54

DOI: 10.1007/s00424-024-03046-4

Similar Assertions

When healthy young men eat a lot of phosphate for five days, their body doesn’t change the levels of several key hormones — so scientists think a different hormone called FGF23 is the main one responding to the extra phosphate.

54

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79%

If healthy young men eat more phosphate-rich food for just five days, their blood phosphate levels go up—and so does a hormone called iFGF23 that helps control phosphate in the body.

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74%