The Claim
Repeated administration of GDF8 and activin A blocking antibodies for 12 weeks in healthy postmenopausal women causes a sustained increase in thigh muscle volume that reverts to baseline levels by 28 weeks after treatment cessation, demonstrating dependency on continuous blockade.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In healthy postmenopausal women, injecting antibodies that block GDF8 and activin A for 12 weeks increases thigh muscle volume, and this increase disappears by 28 weeks after stopping the injections.
See the scientific wording
In healthy postmenopausal women, repeated administration of GDF8 and activin A blocking antibodies for 12 weeks results in a sustained increase in thigh muscle volume that reverses to baseline by 28 weeks after treatment cessation, indicating the effect is dependent on continuous blockade.
When proteins that normally stop muscle growth are blocked, muscle cells start making more protein and growing larger. This growth continues only as long as the blocking agents are present. Once the blockers are removed, the proteins return, stop protein production, and the muscles shrink back to their original size.
What the research says
1 studyWhen postmenopausal women got shots that block two proteins limiting muscle growth, their leg muscles got bigger — but only while they kept getting the shots. Once they stopped, the muscles went back to their original size.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.