Giving rats insulin for a week while keeping their blood sugar normal doesn't change their blood pressure.

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Against

Evidence from Studies

Supporting (1)

13

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13

Seven Days of Euglycemic Hyperinsulinemia Induces Insulin Resistance for Glucose Metabolism but Not Hypertension, Elevated Catecholamine Levels, or Increased Sodium Retention in Conscious Normal Rats

Cohort Study

Animal

1997 Oct

The study gave rats insulin for 7 days while keeping their blood sugar normal, exactly like the claim describes. It found their blood pressure stayed the same (125 mmHg before, 127 mmHg after), which proves the claim is true.

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No contradicting evidence found

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Source Study

Seven Days of Euglycemic Hyperinsulinemia Induces Insulin Resistance for Glucose Metabolism but Not Hypertension, Elevated Catecholamine Levels, or Increased Sodium Retention in Conscious Normal Rats

Score: 13

DOI: 10.2337/diacare.46.10.1572

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Scientists found that when they kept rats with normal blood sugar on high insulin for a week, their stress hormone levels didn't change at all - they stayed exactly the same.

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When researchers kept insulin levels high but blood sugar normal in rats for a week, the rats' bodies didn't hold onto more sodium than usual - their sodium levels stayed steady at about 0.34 mmol.

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Scientists found that keeping insulin levels artificially high for a week made rats develop severe insulin resistance - their bodies became much worse at processing sugar, with glucose uptake dropping by 39% and sugar storage falling by 62%.

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