When people with obesity take a weight-loss drug called liraglutide for 5 weeks, their brain's food-reward area becomes more active when they see food — even after accounting for weight loss, which might mean the brain is fighting back against losing weight.

66

Pro

0

Against

Evidence from Studies

Supporting (1)

66

Community contributions welcome

66

Longer‐term liraglutide administration at the highest dose approved for obesity increases reward‐related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti‐obesity therapies

Randomized Controlled Trial

Human

2019 Nov

The study found that after 5 weeks of liraglutide, the brain's reward area became more active in response to food when accounting for weight loss, which matches what the claim says.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Longer‐term liraglutide administration at the highest dose approved for obesity increases reward‐related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti‐obesity therapies

Score: 66

DOI: 10.1111/dom.13827

Similar Assertions

If someone is obese and takes a weight-loss drug called liraglutide for 5 weeks, their brain doesn’t react differently to pictures of food — at least not if we don’t factor in how much weight they lost.

66

0

86%

When people take liraglutide for weight loss, their brain's 'decision-making' area might become more active as a way to push back against further weight loss — which could be why the pounds stop dropping after a while.

66

0

82%