Scientists found that turning off a specific gene called ptpn6 can fix the problems that too much insulin causes in baby zebrafish - specifically, it helps restore their immune system and insulin signaling that get messed up when there's too much insulin.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Cross-Sectional Study

Animal

2014 Aug

The study shows that when researchers 'turned off' the ptpn6 gene in zebrafish larvae with high insulin levels, it restored the normal function of immune system genes and insulin signaling that were being suppressed by the high insulin - exactly as the claim describes.

Contradicting (0)

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No contradicting evidence found

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Source Study

Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Score: 6

DOI: 10.1530/JOE-14-0178

Similar Assertions

A protein called Ptpn6 helps control whether the body can respond to insulin properly or becomes insulin-resistant in zebrafish with high insulin levels.

6

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Scientists found that a specific gene called ptpn6 (or Shp1) is more active than usual in zebrafish babies with insulin resistance, which goes against what usually happens to immune genes when there's too much insulin.

6

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86%

When zebrafish babies are exposed to too much insulin for a long time, their immune system genes become less active - scientists proved this by looking at which genes are turned on or off.

6

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75%