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Strong Support

In women with a pregnancy complication called preeclampsia, a substance called hyaluronan makes immune cells more inflamed, but two other substances—progesterone and vitamin D—can calm that inflammation down in lab tests.

42
Pro
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Evidence from Studies

Supporting (1)

42

Community contributions welcome

42

Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia.

Cross-Sectional Study
Human
2021 Apr

In a lab test with blood cells from women with preeclampsia, a substance called hyaluronan made the cells more inflamed, but giving them progesterone or vitamin D calmed them down — just like the claim says.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia.

Score: 42
DOI: 10.1016/j.jri.2021.103286

Similar Assertions

When scientists test immune cells from pregnant women with a condition called preeclampsia, adding progesterone or vitamin D to the cells in a lab seems to calm down their inflammation. It’s like turning down the volume on the body’s alarm system.

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In women with a pregnancy complication called preeclampsia, two natural substances—progesterone and vitamin D—may calm down an overactive immune response in certain blood cells, which could help reduce harmful inflammation.

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73%

Scientists found that a lab-grown type of immune cell (called THP-1) acts like the immune cells from pregnant women with preeclampsia — it shows the same signs of inflammation. This makes it a useful tool for studying the condition without using human patients.

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