When scientists test immune cells from pregnant women with a condition called preeclampsia, adding progesterone or vitamin D to the cells in a lab seems to calm down their inflammation. It’s like turning down the volume on the body’s alarm system.

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Evidence from Studies

Supporting (1)

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Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia.

Cross-Sectional Study

Human

2021 Apr

Scientists found that giving progesterone and vitamin D to immune cells from women with preeclampsia calmed down their inflammation, just like the claim said. These hormones helped reduce the signals that cause swelling and damage in the body.

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Source Study

Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 inflammasomes and TLR4-MyD88-NF-κB pathway in monocytes from pregnant women with preeclampsia.

Score: 42

DOI: 10.1016/j.jri.2021.103286

Similar Assertions

In women with a pregnancy complication called preeclampsia, two natural substances—progesterone and vitamin D—may calm down an overactive immune response in certain blood cells, which could help reduce harmful inflammation.

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When women have preeclampsia during pregnancy, their immune cells called monocytes are more active and produce more inflammatory signals than those in pregnant women without this condition, suggesting their bodies are in a constant low-level inflammatory state.

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In women with a pregnancy complication called preeclampsia, a substance called hyaluronan makes immune cells more inflamed, but two other substances—progesterone and vitamin D—can calm that inflammation down in lab tests.

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79%

Scientists found that a lab-grown type of immune cell (called THP-1) acts like the immune cells from pregnant women with preeclampsia — it shows the same signs of inflammation. This makes it a useful tool for studying the condition without using human patients.

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76%