When scientists block the production of ribosomes in human muscle cells grown in a dish, the cells can't get bigger even when given signals that normally make them grow—suggesting that making ribosomes is essential for muscle cells to enlarge.

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46

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46

Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro.

Cohort Study

Human

2016 Apr 15

Scientists blocked a key step in making ribosomes (cellular protein factories) in human muscle cells in a dish, and the cells stopped growing bigger—even when given growth signals. This proves ribosome production is needed for muscle cells to enlarge.

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Source Study

Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro.

Score: 46

DOI: 10.1152/ajpendo.00486.2015

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