The Claim

In human muscle cells in culture, inhibition of ribosomal RNA synthesis by CX-5461 completely abolishes growth factor-induced cell enlargement, indicating that ribosome biogenesis is necessary for myotube hypertrophy.

Source: Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
46score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

When scientists block the production of ribosomes in human muscle cells grown in a dish, the cells can't get bigger even when given signals that normally make them grow—suggesting that making ribosomes is essential for muscle cells to enlarge.

See the scientific wording

In human muscle cells in culture, blocking ribosomal RNA synthesis with CX-5461 completely abolishes growth factor-induced cell enlargement, suggesting ribosome biogenesis is necessary for myotube hypertrophy.

What the research says

1 study

  1. Study: Ribosome biogenesis may augment resistance training-induced myofiber hypertrophy and is required for myotube growth in vitro.

    Scientists blocked a key step in making ribosomes (cellular protein factories) in human muscle cells in a dish, and the cells stopped growing bigger—even when given growth signals. This proves ribosome production is needed for muscle cells to enlarge.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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