When sodium oleate is introduced directly into the intestines of rats, it causes measurable damage to the intestinal lining, shown by higher levels of lactate dehydrogenase and leakage of Evans blue...
Mechanism
Synthesis from 1 study
Sodium oleate acts like soap in the gut, breaking apart the fatty walls between gut cells. Other fats don’t do this because they’re either not in the right form or too small. This lets fluids and dyes leak through, which is what the tests detected.
Most probable mechanism
Sodium oleate acts like a soap in the gut, breaking apart the fatty layers that hold gut cells together. This causes gaps to form between the cells, letting fluids and molecules leak out. Other similar fats don’t do this because they’re not in a form that can dissolve these fatty layers as effectively.
Sodium oleate, as a sodium salt of oleic acid, dissociates in the intestinal lumen to form oleate anions and sodium ions, increasing local anionic surfactant concentration
Oleate anions insert into and disrupt the phospholipid bilayer of intestinal epithelial cell membranes due to their amphipathic structure
Membrane disruption increases paracellular permeability, allowing intracellular enzymes like lactate dehydrogenase to leak into the lumen and enabling Evans blue dye to cross the epithelial barrier
Evidence from Studies
Supporting (1)
Community contributions welcome
Satiety from fat? Adverse effects of intestinal infusion of sodium oleate.
Contradicting (0)
Community contributions welcome
Gold Standard Evidence Needed
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