The Claim
The co-administration of 1 g L-citrulline and 1 g L-arginine results in a higher peak plasma L-arginine concentration at 1 hour post-ingestion compared to the administration of 2 g of either L-citrulline or L-arginine alone in healthy males.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When healthy men take 1 gram of L-citrulline and 1 gram of L-arginine together, their blood L-arginine levels reach a higher peak after one hour than when they take 2 grams of either amino acid by itself.
See the scientific wording
The combination of 1 g L-citrulline and 1 g L-arginine produces a higher peak plasma L-arginine concentration at 1 hour post-ingestion than either amino acid administered alone at 2 g, indicating a synergistic short-term effect on bioavailability in healthy males.
When L-citrulline and L-arginine are taken together, L-citrulline blocks an enzyme that breaks down L-arginine, allowing more L-arginine to enter the bloodstream without being destroyed in the gut or liver.
What the research says
1 studyWhen you take 1 gram of citrulline and 1 gram of arginine together, your body ends up with more arginine in your blood after one hour than if you took 2 grams of just one of them alone — they work better as a team.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.