Back to "Adgra1−/− male mice exhibited significan..."
Strong Support
descriptive
History

When the ADGRA1 gene is turned off in male mice, they burn more energy and generate more body heat, leading to significantly lower body weight over time—even though they eat the same amount and move...

14
Pro
0
Against

Evidence from Studies

Supporting (1)

14

Community contributions welcome

14

ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus–pituitary–thyroid axis in male mice

Cohort Study
Animal & In Vitro
2021 Apr 6

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Sign up to see full verdict

Source Study

ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus–pituitary–thyroid axis in male mice

Score: 14
DOI: 10.1038/s41419-021-03634-7