When the THRB protein is removed from a specific type of pituitary cell in the lab, more THRA protein binds to the DNA region that controls the Tshb gene.

Evidence from Studies

Supporting (1)

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Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.

Computational/Algorithm Study

In Vitro

2012 Jun

When the THRB protein is removed from these thyroid-regulating cells, another similar protein called THRA moves in to take its place on the same gene switch. This shows the cells use THRA as a backup when THRB isn’t around.

Contradicting (0)

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No contradicting evidence found

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Source Study

Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.

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DOI: 10.1210/me.2011-1290

Similar Assertions

In a laboratory cell line derived from pituitary tissue, removing both versions of the thyroid hormone receptor prevents the hormone T3 from suppressing the production of Tshb mRNA, even when T3 is present at very high levels.

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88%

In a laboratory cell line derived from pituitary tissue, removing the thyroid hormone receptor beta prevents T3 from suppressing the production of Tshb mRNA, while removing receptor alpha does not, indicating that receptor beta is required for T3 to reduce Tshb mRNA levels under physiological conditions.

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83%