The Claim
Insulin does not increase (Na+ + K+)-ATPase activity in isolated frog skeletal muscle membranes when the enzyme is already maximally activated by high concentrations of Na+ (100 mM), K+ (20 mM), and ATP (2 mM), indicating that insulin enhances the enzyme's sensitivity to activators rather than its maximum catalytic capacity.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Insulin doesn't boost the pump activity in frog muscle cells when it's already running at full speed, which suggests insulin helps the pump respond better to signals instead of making it work harder.
See the scientific wording
Insulin does not stimulate (Na+ + K+)-ATPase activity in isolated frog skeletal muscle membranes when the enzyme is already maximally activated by high concentrations of Na+ (100 mM), K+ (20 mM), and ATP (2 mM), suggesting insulin enhances enzyme sensitivity rather than maximum catalytic capacity.
What the research says
1 studyStudy: Effect of insulin upon membrane‐bound (Na+ + K+)‐ATPase extracted from frog skeletal muscle.
The study shows insulin doesn’t boost the enzyme when it’s already working as hard as it can, suggesting insulin makes the enzyme more sensitive, not stronger. This matches the claim.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.