mechanistic
Analysis v1
Strong Support
Insulin doesn't boost the pump activity in frog muscle cells when it's already running at full speed, which suggests insulin helps the pump respond better to signals instead of making it work harder.
10
0
Evidence from Studies
Supporting (1)
10
Community contributions welcome
10
Effect of insulin upon membrane‐bound (Na+ + K+)‐ATPase extracted from frog skeletal muscle.
Cross-Sectional Study
Animal
1975 OctThe study shows insulin doesn’t boost the enzyme when it’s already working as hard as it can, suggesting insulin makes the enzyme more sensitive, not stronger. This matches the claim.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.