When mice liver cells are exposed to two specific drugs together, they produce a harmful chemical that damages the cell’s energy factories, causing the cells to die. But if you add a substance that neutralizes that harmful chemical, you can stop the cell death.

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Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes

Case-Control Study

Animal

2014

When two common drugs (efavirenz and isoniazid) are taken together, they can damage liver cells by creating a harmful chemical called peroxynitrite, which bursts mitochondria and kills cells—but antioxidants that mop up this chemical can prevent the damage.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes

Score: 12

DOI: 10.1016/j.redox.2014.03.003

Similar Assertions

When two specific drugs are taken together, they can damage liver cells in mice by disrupting their energy factories and causing cell death — but each drug alone, at the same dose, doesn't do anything harmful. This means the danger only shows up when both are present.

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90%

A drug called efavirenz can block a key energy process in mouse liver cells at a specific dose, and while it doesn’t hurt the cells by itself, it makes them much more likely to get damaged when combined with another drug called isoniazid.

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72%