The Claim
The ghrelin/LEAP2 ratio increases during fasting to promote hunger and energy conservation and decreases after meals to promote satiety, functioning as a physiological rheostat for energy balance.
What the research says
Roughly balanced
Support and challenge are close. The picture may shift as more studies come in.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
The ratio of ghrelin to LEAP2 rises when a person has not eaten and falls after eating, directly regulating hunger and energy conservation.
See the scientific wording
The ghrelin/LEAP2 ratio dynamically shifts in response to nutritional status, increasing during fasting to promote hunger and energy conservation and decreasing after meals to promote satiety, suggesting it functions as a physiological rheostat for energy balance.
When you haven't eaten, your stomach releases ghrelin and your liver releases less LEAP2, which together turn on hunger signals in the brain and slow down energy burning; after you eat, ghrelin drops and LEAP2 rises, which turns off hunger signals and speeds up energy burning, keeping your body's energy in balance.
What the research says
1 studyStudy: The Ghrelin-LEAP2 System in Obesity and Diabetes: Pathophysiological Roles and Therapeutic Potential
When you're hungry, your body makes more ghrelin and less LEAP2 to make you want to eat; after eating, it does the opposite — less ghrelin and more LEAP2 — to tell you you're full. This study shows that's exactly how the system works.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.