The Claim
In young, healthy men aged 18–25, daily supplementation with 20 grams of creatine monohydrate during one week of upper-limb immobilization attenuates the loss of lean tissue mass by approximately 4.6 percentage points compared to placebo.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In young healthy men aged 18–25, taking 20 grams of creatine monohydrate daily for one week during arm immobilization reduces the loss of muscle mass by about 4.6 percentage points compared to taking a placebo.
See the scientific wording
In young, healthy men aged 18–25, daily supplementation with 20 grams of creatine monohydrate during one week of upper-limb immobilization likely attenuates the loss of lean tissue mass by approximately 4.6 percentage points compared to placebo, preserving muscle mass during short-term disuse.
Creatine fills muscle cells with energy reserves that keep muscles working even when they're not moving. This energy support triggers signals that turn on genes responsible for building muscle proteins, while also helping repair cells that break down during inactivity. Together, these actions stop muscle from shrinking.
What the research says
1 studyWhen young men had their arm stuck in a cast for a week, those who took 20 grams of creatine daily actually gained a little muscle, while those who took a placebo lost muscle. Creatine helped prevent about 4.6% more muscle loss than nothing.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.