The Claim

In young, healthy men aged 18–25, daily supplementation with 20 grams of creatine monohydrate during one week of upper-limb immobilization reduces the decline in elbow extensor strength by 14.2 percentage points compared to placebo.

Source: Effect of Creatine Supplementation During Cast-Induced Immobilization on the Preservation of Muscle Mass, Strength, and Endurance

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
57score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Cause and effect
1 study reviewed
In plain English

In young healthy men aged 18–25, taking 20 grams of creatine monohydrate daily for one week while the arm is immobilized results in a 14.2 percentage point smaller loss of elbow extensor strength compared to taking a placebo.

See the scientific wording

In young, healthy men aged 18–25, daily supplementation with 20 grams of creatine monohydrate during one week of upper-limb immobilization likely reduces the decline in elbow extensor strength by 14.2 percentage points compared to placebo, preserving muscle function during disuse.

Why this might work

Creatine enters muscle cells and gets converted into a high-energy storage molecule that quickly replenishes the fuel used for muscle contractions. This keeps muscles strong even when they are not being used. At the same time, creatine triggers signals that increase the production of muscle proteins and add more nuclei to muscle fibers, helping them resist breakdown and maintain size.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Effect of Creatine Supplementation During Cast-Induced Immobilization on the Preservation of Muscle Mass, Strength, and Endurance

    When young men had their arm in a cast for a week, those who took creatine lost much less arm strength than those who took a sugar pill — specifically, 14% less loss, which is exactly what the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

Fit Body Science verdict — we translate health claims into clear verdicts backed by peer-reviewed research.

Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.