When your muscles get tired and burn during exercise, they release signaling chemicals (like IL-6) that might help repair and grow muscle by activating nearby stem cells — but we’re still figuring out if this really happens in people.

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Evidence from Studies

Supporting (1)

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Potential Mechanisms for a Role of Metabolic Stress in Hypertrophic Adaptations to Resistance Training

Narrative Review

2013 Mar

This study says that when you lift weights really hard and your muscles burn, it creates chemicals (like IL-6) that might help your muscles grow bigger—even if we don’t have direct proof yet in humans. That matches what the claim says.

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Potential Mechanisms for a Role of Metabolic Stress in Hypertrophic Adaptations to Resistance Training

Score: 1

DOI: 10.1007/s40279-013-0017-1

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