Scientists found that when they gave zebrafish babies a high amount of human insulin, the fish stopped responding to insulin properly - similar to what happens in humans with diabetes.

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Evidence from Studies

Supporting (1)

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Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Cross-Sectional Study

Animal

2014 Aug

The study directly tested whether giving zebrafish larvae high doses of human insulin would cause insulin resistance, and it did. This proves the zebrafish model can work with human insulin and shows the same problem that happens in humans with type 2 diabetes.

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No contradicting evidence found

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Source Study

Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.

Score: 6

DOI: 10.1530/JOE-14-0178

Similar Assertions

Scientists use tiny zebrafish with a condition similar to high insulin levels to study how insulin resistance works and how the immune system affects metabolic diseases, without needing obese animals.

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When zebrafish babies are exposed to too much insulin for a long time, their immune system genes become less active - scientists proved this by looking at which genes are turned on or off.

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73%