The Claim
Exposure of zebrafish larvae to high-dose human recombinant insulin induces insulin resistance, demonstrating that the zebrafish model responds to human insulin and replicates mammalian insulin resistance phenotypes.
What the research says
Roughly balanced
Support and challenge are close. The picture may shift as more studies come in.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Scientists found that when they gave zebrafish babies a high amount of human insulin, the fish stopped responding to insulin properly - similar to what happens in humans with diabetes.
See the scientific wording
Zebrafish larvae exposed to high-dose human recombinant insulin develop insulin resistance, demonstrating that the zebrafish model is sensitive to human insulin and can replicate key features of insulin resistance observed in mammalian systems
What the research says
1 studyStudy: Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish.
The study directly tested whether giving zebrafish larvae high doses of human insulin would cause insulin resistance, and it did. This proves the zebrafish model can work with human insulin and shows the same problem that happens in humans with type 2 diabetes.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.