White kids who have a certain genetic change (R46L) in the PCSK9 gene tend to have lower 'bad' cholesterol levels from a young age—this finding is from the abstract summary - full study details were...

Pro

Against

Evidence from Studies

Supporting (1)

Community contributions welcome

Relation of PCSK9 mutations to serum low-density lipoprotein cholesterol in childhood and adulthood (from The Bogalusa Heart Study).

Cohort Study

Human

2007 Jul 1

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Relation of PCSK9 mutations to serum low-density lipoprotein cholesterol in childhood and adulthood (from The Bogalusa Heart Study).

Score: 45

DOI: 10.1016/J.AMJCARD.2007.02.057