In White people, having genes that naturally lower PCSK9 are linked to a lower chance of developing leg circulation problems, possibly because of how these genes affect cholesterol.

People who naturally have a broken PCSK9 gene — which keeps their bad cholesterol low their whole life — are much less likely to get heart disease, and this seems to be true for people of many different backgrounds.

People born with a certain genetic quirk that lowers their bad cholesterol over their whole life seem to have a lower chance of developing a dangerous belly blood vessel problem called an abdominal aortic aneurysm.

White adults with a certain gene variant have lower bad cholesterol and are nearly half as likely to get heart disease over 15 years — showing that even a small, lifelong drop in cholesterol can really protect your heart.

Black adults with a certain genetic mutation have much lower bad cholesterol and are way less likely to get heart disease over 15 years — this shows that keeping cholesterol low from an early age could really protect your heart, even if you're at higher risk.

People born with a certain gene change that lowers their bad cholesterol over their whole life might have a lower chance of getting dementia, and this could be because of better blood vessel health in the brain.