The Claim

Post-menopausal women have significantly higher baseline arterial stiffness and vascular dysfunction than pre/peri-menopausal women, as measured by increased intima-media thickness, carotid artery diameter, and local carotid pulse wave velocity.

Source: Beneficial effects of one-year menaquinone-7 supplementation on vascular stiffness and blood pressure in post-menopausal women

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
78score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

Description
1 study reviewed
In plain English

Women after menopause have stiffer arteries and reduced blood vessel function compared to women before or during menopause, as shown by thicker artery walls, larger artery size, and faster pulse wave speed in the neck arteries.

See the scientific wording

Post-menopausal women exhibit significantly greater baseline arterial stiffness and vascular dysfunction compared to pre/peri-menopausal women, as evidenced by higher intima-media thickness, carotid artery diameter, and local carotid PWV, suggesting menopause accelerates vascular aging.

Why this might work

After menopause, the drop in estrogen causes less active matrix Gla protein in artery walls, which allows calcium to build up. This calcium hardens the elastic layers of the arteries and makes them stiff, increasing pressure and reducing their ability to expand and recoil.

Supported mechanismbased on 1 study

What the research says

1 study
  1. Study: Beneficial effects of one-year menaquinone-7 supplementation on vascular stiffness and blood pressure in post-menopausal women

    The study found that women after menopause already had stiffer arteries and thicker artery walls than women before or during menopause — even before taking any supplement. This supports the idea that menopause makes blood vessels age faster.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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